Biomedical and Biotechnology Research Journal (BBRJ)

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 6  |  Issue : 2  |  Page : 170--174

Impact of Proinflammatory Cytokines: (Interleukin 6, Interleukin 1α, and Interleukin 1β) on Biochemical Parameters in Severe Acute Respiratory Syndrome Coronavirus 2 Patients in Iraq


Ismael Raheem Al-Muhana1, Mohanad Mohsin Ahmed2, Ishaq Raheem Al-Muhana3, Baraa Akeel AL-Hasan4 
1 Department of Microbiology, College of Veterinary Medicine, Kufa University, Najaf, Iraq
2 Department of Microbiology, College of Medicine, Karbala University, Karbala, Iraq
3 Department of Veterinary Genetic, Institute of Health sciences, Ankara University, Ankara, Turkey
4 Department of Medical Laboratory Technology, College of Medical Technology, The Islamic University, Najaf, Iraq

Correspondence Address:
Ismael Raheem Al-Muhana
Department of Microbiology, College of Veterinary Medicine, Kufa University, Najaf
Iraq

Background: The cytokine storm and specific biochemical results were both observed during Coronavirus disease 2019 (COVID-19) infection. The aim of this study was to see if there was any correlation between biochemical findings and cytokine levels. Methods: A total of 65 COVID-19 patients, including 32 males and 33 females with ages between (16 and 90 years) were enrolled in this study. Between December 2020 and February 2021, these patients were admitted to Al-Amal Specialized Hospital or ward of COVID-19 care in Al-Sader Hospital. These patients were classified into severe/critical (43 cases), mild/moderate (22 cases) according to the guidelines released by National Health World depending on SpO2 percentage. The biochemical indices were measured using FUJI DRI-CHEM NX500 automated clinical chemistry analyzer (FUJIFILM, Japan). The proinflammatory cytokine (interleukin-6 [IL-6], IL-1α, and IL-1β) were measured using ELISA technique. Results: IL-6 serum levels were negatively correlated with SpO2 (P = 0.002, R = - 0.372) and serum albumin (P = 0.034, R = - 0.301). IL-1α serum levels showed significant negative correlation with serum albumin levels (P = 0.039, R = - 0.259). Furthermore, a positive correlation found between IL-1β serum with serum levels of both AST and LDH (P = 0.049; R = 0.255; P = 0.054; R = 0.320 respectively). Discussion: Increased IL-6 serum levels have a direct impact on SpO2 percentage and serum albumin. Whereas the elevated levels of both IL-1α and IL-1β are a possible cause of acute inflammation and liver damage in COVID-19. Conclusions: This study further confirms the growing evidence on the direct role of proinflammatory cytokines in the biochemical changes shown in COVID-19.


How to cite this article:
Al-Muhana IR, Ahmed MM, Al-Muhana IR, AL-Hasan BA. Impact of Proinflammatory Cytokines: (Interleukin 6, Interleukin 1α, and Interleukin 1β) on Biochemical Parameters in Severe Acute Respiratory Syndrome Coronavirus 2 Patients in Iraq.Biomed Biotechnol Res J 2022;6:170-174


How to cite this URL:
Al-Muhana IR, Ahmed MM, Al-Muhana IR, AL-Hasan BA. Impact of Proinflammatory Cytokines: (Interleukin 6, Interleukin 1α, and Interleukin 1β) on Biochemical Parameters in Severe Acute Respiratory Syndrome Coronavirus 2 Patients in Iraq. Biomed Biotechnol Res J [serial online] 2022 [cited 2022 Jun 26 ];6:170-174
Available from: https://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=2;spage=170;epage=174;aulast=Al-Muhana;type=0