• Users Online: 361
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2022  |  Volume : 6  |  Issue : 2  |  Page : 289-294

Comparison of microalbuminuria, creatinine, and glomerular filtration rate between sickle cell disease patients and healthy individuals


1 Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani; Departments of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan
2 Department of Medical Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira; Department of Parasitology, Blue Nile National Institute for Communicable Diseases, University of Gezira, Wad Medani, Sudan
3 Department of Pathology, College of Medicine, Karary University, Khartoum, Sudan
4 Microbiology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan

Correspondence Address:
Mubarak Elsaeed Mustafa Elkarsany
Department of Pathology, College of Medicine, Karary University, Khartoum
Sudan
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_67_22

Rights and Permissions

Background: Sickle cell disease is related to many health issues (such as stroke, severe infections, and sickle cell crisis) and elevated risk of death. This study was aimed to investigate and compare microalbuminuria (MAU), creatinine, and glomerular filtration rate (GFR) between sickle cell disease (SCD) patients and healthy individuals. Methods: A total of 156 cases and 156 control subjects were included. MAU, creatinine, GFR, and body mass index (BMI) were measured. Results: The estimated levels of MAU and creatinine were significantly higher in cases than controls, but the mean of BMI and GFR was significantly lower in cases than the control group. In patients of sickle cell disease, the mean MAU, GFR, creatinine, and BMI levels in females, rural area residents, and subjects aged 2–13 years were higher than controls, P < 0.05. MAU and GFR were also higher (P < 0.05) in males and subjects aged 14–25 years of study cases than controls. Conclusion: Accordingly, this study indicated the impact of SCD in MAU, creatinine, GFR, and BMI, which are significant in the diagnosis of nephropathy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed398    
    Printed52    
    Emailed0    
    PDF Downloaded67    
    Comments [Add]    

Recommend this journal