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ORIGINAL ARTICLE
Year : 2022  |  Volume : 6  |  Issue : 1  |  Page : 132-137

Correlation between platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with hematological parameters in multiple myeloma patients


1 KSHEMA Center for Genetic Services, K. S. Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, Karnataka, India
2 Department of Oncology, K. S. Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, Karnataka, India
3 Department of Pathology, K. S. Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, Karnataka, India

Correspondence Address:
Deyyenthody Prashanth Shetty
KSHEMA Center for Genetic Services, K. S. Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_275_21

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Background: Multiple myeloma (MM) is a malignant neoplasm of clonal plasma cells. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors and biomarkers of systemic inflammation. The aim of this study was to determine a correlation between NLR, PLR, and hematological parameters in patients with MM. Methods: The clinical data of 50 MM patients were collected from hospital medical records. NLR and PLR were calculated from data obtained from clinical records. Results: The median age was 60 years at diagnosis. The study cohort was divided into two groups based on cutoff points taken from previously published data (NLR: 2.56 and PLR: 157). Erythrocyte sedimentation rate, blood urea, uric acid, platelet count, and absolute neutrophil count were higher in patients with high NLR than in patients with low NLR. A significant association between NLR and blood urea was seen (P < 0.0018). Pearson's correlation analysis revealed a strong positive correlation for blood urea and NLR, uric acid and NLR, and blood urea and PLR. Conclusion: Thus, combined applications of NLR and PLR could be used as a cost-effective diagnostic predictor of MM patients.


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