• Users Online: 199
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2021  |  Volume : 5  |  Issue : 4  |  Page : 458-462

Correlation of serum lipoprotein (a) levels with angiographic lesion severity in coronary artery disease


1 Department of Biochemistry, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India
2 Department of Cardiology, Justice KS Hegde Charitable Hospital, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India
3 Nitte University Center for Science Education and Research, Nitte (Deemed to be University), Paneer Campus, Mangalore, Karnataka, India
4 Central Research Laboratory, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India
5 Department of Community Medicine, KS Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India

Correspondence Address:
Sukanya Shetty
Department of Biochemistry, K S Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore - 575 018, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_207_21

Rights and Permissions

Background: The several epidemiological and meta-analysis studies suggested that the elevated lipoprotein (a) (Lp(a)) level is associated to cause the coronary artery disease (CAD). However, the role of this pro-atherogenic Lp (a) in regulating the severity of angiographic lesions in CAD is poorly understood. This study aimed to estimate the serum Lp (a) level and find its correlation with angiographic lesion severity in subjects with CAD. Methods: In this cross-sectional study, a total of 107 subjects angiographic lesion severity was determined by SYNergy between percutaneous coronary interventions with TAXUS and cardiac surgery (SYNTAX) scoring system and grouped into mild (<22) and severe (≤22) based on the SYNTAX score. The serum Lp (a) concentration in subjects' serum was measured by immunoturbidimetric assay. Results: The median Lp (a) level of all subjects was found to be 14.8 mg/dL, it was higher in severe angiographic lesion group (18.9 mg/dL, interquartile range [IQR]: 12.3–24.4) when compared to mild group (13.7 mg/dL, IQR: 6.6–18.6). The Spearman correlation analysis revealed that the relationship between serum Lp (a) level and angiographic lesion severity in mild and severe subjects is not statistically significant except with the mild group female subjects. Conclusions: Overall, this study does not support the association of angiographic lesion severity with serum Lp (a) levels in CAD. To infer precisely, similar studies with more subjects are needed to confirm this study's findings.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed168    
    Printed0    
    Emailed0    
    PDF Downloaded27    
    Comments [Add]    

Recommend this journal