| ORIGINAL ARTICLE |
|
| Year : 2021 | Volume
: 5
| Issue : 4 | Page : 405-411 |
|
|
Comparison of anti-inflammatory activities of biogenic gymnema sylvestre- and panicum sumatrense-mediated titanium dioxide nanoparticles
Moses Stella Bharathy, Gnanasekar Dayana Jeyaleela, Joseph Devaraj Rosaline Vimala, Aranganathan Agila, Sagaya Adaikalaraj Margrat Sheela
Department of Chemistry, Holy Cross College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, India
Correspondence Address:
Moses Stella Bharathy
Department of Chemistry, Holy Cross College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli - 620 002, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/bbrj.bbrj_164_21
|
|
|
Background: Studying the anti-inflammatory effect of the wound-healing property in immune responsive compounds such as interleukins and cytokinins plays a vital role in targeting various inflammatory diseases such as asthma, rheumatoid arthritis, tuberculosis, and periodontitis. The goal of the present work is to compare the anti-inflammatory activity of Gymnema sylvestre (GS)- and Panicum sumatrense (PS)-mediated titanium dioxide (TiO2) nanoparticles (NPs) by in vitro studies. Methods: G. sylvestre- and P. sumatrense-mediated TiO2 NPs were synthesized by Greener method. The synthesized TiO2 NPs were spectroscopically characterized such as Ultraviolet-visible, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscope (SEM), and Energy Dispersive X-Ray Analysis (EDAX). The in vitro anti-inflammatory activities of GS-TiO2 and PS-TiO2 NPs were carried out by albumin denaturation assay. Results: The size of G. sylvestre-mediated TiO2 (GS-TiO2) NPs was found to be 16–22 nm and that of P. sumatrense (PS-TiO2)-mediated NPs was in the range of 26–32 nm. Rectangle, hexagonal, and square types of NPs were recorded in the SEM analysis of both the GS-TiO2 and PS-TiO2. When comparing the X-ray powder diffraction and EDAX results of GS-TiO2 and PS-TiO2, G. sylvestre-mediated TiO2 showed less impurity and along with that, it revealed pure titanium in 50.50% and oxygen in 35.54%. Similarly, G. sylvestre-mediated TiO2 nanoparticles exhibited 91.52% of inhibitory effect on protein denature (in vitro anti-inflammatory activity), whereas P. sumatrense (PS-TiO2)-mediated NPs showed only 84.80%. Conclusion: The overall study concludes that G. sylvestre-mediated TiO2 nanoparticle can have a scope in alternative treatment/remedy for inflammation diseases.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
