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Year : 2021  |  Volume : 5  |  Issue : 3  |  Page : 260-266

Contrasting role of autophagy in different types of cancer: A review toward biomarkers and therapeutic improvement

University of Calcutta, Kolkata, West Bengal, India

Correspondence Address:
Pallab Chakraborty
University of Calcutta, Kolkata, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bbrj.bbrj_123_21

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Autophagy, the major cellular pathway, is known not only for the degradation and recovering in mammalian cells but also it maintains the cellular energy homeostasis and produces the building blocks. However, if the process starts destroying the essential ones other than the bad proteins, then the normal cellular control will be lost, and here, we see similar kinds of phenomena in cancer. It has been reported by previous papers related to this field that the novel pathway has paradoxical role in cancer, as it acts as both tumor promoter and suppressor. Therefore, autophagy could provide new resources for the improvement of antitumor drugs in near future. Here, in this review, we will know about the autophagy process in brief. We will also try to understand the contrasting role of autophagy in different cancers types, its significance as prognostic markers and its therapeutic implication for cancer treatment in the near future.

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